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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 376-380 doi: 10.1007/s11684-012-0228-0
The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.
关键词: FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis
The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 412-425 doi: 10.1007/s11684-018-0650-z
Transcription factor networks have evolved in order to control, coordinate, and separate, the functions of distinct network modules spatially and temporally. In this review we focus on the MYC network (also known as the MAX-MLX Network), a highly conserved super-family of related basic-helix-loop-helix-zipper (bHLHZ) proteins that functions to integrate extracellular and intracellular signals and modulate global gene expression. Importantly the MYC network has been shown to be deeply involved in a broad spectrum of human and other animal cancers. Here we summarize molecular and biological properties of the network modules with emphasis on functional interactions among network members. We suggest that these network interactions serve to modulate growth and metabolism at the transcriptional level in order to balance nutrient demand with supply, to maintain growth homeostasis, and to influence cell fate. Moreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the activity of the network as a whole, leading to tumor initiation, progression and maintenance.
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities. It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network. Much is known about ethylene, one of the most important metabolites promoting the ripening of climacteric fruits. However, the dynamic interplay between phytohormones also plays an important part. Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening. Here, we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.
关键词: climacteric fruit ripening / phytohormones / TFs / epigenetic modifications
Yinglin JI, Mingyang XU, Aide WANG
《农业科学与工程前沿(英文)》 页码 314-334 doi: 10.15302/J-FASE-2021386
关键词: climacteric fruit ripening phytohormones TFs epigenetic modifications
Characterization of chromatin accessibility in psoriasis
《医学前沿(英文)》 2022年 第16卷 第3期 页码 483-495 doi: 10.1007/s11684-021-0872-3
Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN
《医学前沿(英文)》 2009年 第3卷 第2期 页码 148-152 doi: 10.1007/s11684-009-0032-7
关键词: gene X-linked inhibitor of apoptosis protein associated factor-1 (XAF1) promoter transcription regulation
Targeting “undruggable” c-Myc protein by synthetic lethality
Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu
《医学前沿(英文)》 2021年 第15卷 第4期 页码 541-550 doi: 10.1007/s11684-020-0780-y
关键词: synthetic lethality undruggable transcription factor c-Myc
The genetic regulation of skeletal muscle development: insights from chicken studies
Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 295-304 doi: 10.15302/J-FASE-2017159
关键词: chicken epigenetic modification miRNAs skeletal muscle development SNP transcription factor
Genetic biosensors for small-molecule products: Design and applications in high-throughput screening
Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang
《化学科学与工程前沿(英文)》 2017年 第11卷 第1期 页码 15-26 doi: 10.1007/s11705-017-1629-z
关键词: biosensor small molecule product transcription factor riboswitch high-throughput screening
Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI
《农业科学与工程前沿(英文)》 2014年 第1卷 第2期 页码 104-113 doi: 10.15302/J-FASE-2014003
关键词: nuclear reprogramming somatic cell transcription factors transcriptomics
Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis
Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 475-479 doi: 10.1007/s11684-009-0086-6
关键词: ulcerative colitis signal transducer and activator of transcription 6 (STAT6) nuclear factor-κ B p65 (NF-κ B p65)
转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化 Article
Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš
《工程(英文)》 2024年 第32卷 第1期 页码 58-69 doi: 10.1016/j.eng.2023.09.019
Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead box protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liver, creating a regulatory transcriptional loop. The Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase genes. Our in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studied in this work confirms a significant enrichment of these transcription factors specifically in the liver. Our previous studies identified HNF1A as a master regulator of fucosylation, glycan branching, and galactosylation of plasma glycoproteins. Here, we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan phenotype. We used the state-of-the-art clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1A, HNF4A, and FOXA2 genes in HepG2 cells—a human liver cancer cell line. The results show that the downregulation of all three genes individually and in pairs affects the transcriptional activity of many glyco-genes, although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan structures. The effect is better seen as an overall change in the total HepG2 N-glycome, primarily due to the extension of biantennary glycans. We propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan structure. We also propose a model showing feedback loops with the mutual activation of HNF1A–FOXA2 and HNF4A–FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.
关键词: Clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) Epigenetics Hepatocyte nuclear factor 1 alpha (HNF1A) Hepatocyte nuclear factor 4 alpha (HNF4A) Forkhead box protein A2 (FOXA2) N-glycosylation HepG2 cells
LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes
Shiguo XIAO; Shaohong LI
《结构与土木工程前沿(英文)》 2022年 第16卷 第7期 页码 871-881 doi: 10.1007/s11709-022-0863-8
关键词: slope stability safety factor failure criterion least square support vector machine
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
《医学前沿(英文)》 2023年 第17卷 第2期 页码 317-329 doi: 10.1007/s11684-022-0931-4
关键词: lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis
The calculation of equivalence factor for ecological footprints in China: a methodological note
Moucheng LIU,Wenhua LI,Dan ZAHNG,Ning SU
《环境科学与工程前沿(英文)》 2015年 第9卷 第6期 页码 1015-1024 doi: 10.1007/s11783-014-0670-0
关键词: ecological footprint equivalence factor net primary production biological capacity land types
标题 作者 时间 类型 操作
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC
期刊论文
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC
Yinglin JI, Mingyang XU, Aide WANG
期刊论文
Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines
Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN
期刊论文
Targeting “undruggable” c-Myc protein by synthetic lethality
Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu
期刊论文
The genetic regulation of skeletal muscle development: insights from chicken studies
Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG
期刊论文
Genetic biosensors for small-molecule products: Design and applications in high-throughput screening
Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang
期刊论文
Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review
Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI
期刊论文
Expression of STAT6 and NF-κB p65 in the colon mucosa of patients with ulcerative colitis
Rui ZHU MD, Heng FAN MD, Lin SHEN MD, Jianguo LIU BD, Jia ZHAO MM,
期刊论文
转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化
Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš
期刊论文
LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes
Shiguo XIAO; Shaohong LI
期刊论文
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
期刊论文